Born in Louisville, Kentucky, Pope attended the common schools and was graduated from St. Joseph's College, Bardstown, Kentucky. He studied law. He was admitted to the bar in 1827 and commenced practice in Louisville. He declined the position of Secretary of State tendered by Gov. John Breathitt in 1832.
Pope was elected as a Jacksonian to the Twenty-third Congress (March 4, 1833 – March 3, 1835). He was an unsuccessful candidate for reelection in 1834.
Pope was elected a member of the Kentucky House of Representatives in 1836. He resumed the practice of law. He died in Louisville of heart failure on May 4, 1841, and was interred in Cave Hill Cemetery.