September 21st
- 1788 – Margaret Taylor born.
- 1848 – Columbus P. Chastain born.
- 1852 – John Chambers died, aged 71.
- 1887 – William Preston died, aged 70.
- 1891 – John Bryan Bowman died, aged 66.
- 1906 – Thomas M. Doherty died, aged 37.
- 1947 – Marsha Norman born.
- 1956 – Jack Givens born.
- 1959 – Abraham Flexner died, aged 92.
- 1966 – Billy Lane Lauffer died, aged 20.